SCIENTIFIC PROGRAM
November 3rd – 5th,2022
Thursday, November 3rd
Friday, November 4th
Saturday, November 5th
Thursday, November 3rd
8.45
WELCOME
9.00
OPENING ONCOTRANS
Jean-Louis Merlin (Nancy) & Pierre Fumoleau (Strasbourg)
9.30
OPENING ONCOTRANS
SESSION 1
”NANOMEDICINE, RADIOBIOLOGY”
Chairpersons: Muriel Barberi-Heyob (Nancy) & Céline Mirjolet (Dijon)
9.45
10.15
PLENARY 1.1
Tumor sensitization and reoxygenation with gadolinium-containing zeolites nanocrystals: a new theranostic strategy for glioblastoma
Samuel Valable (Caen)
10.20
10.50
PLENARY 1.2
Impairing DNA repair as an innovative radiosensitization strategy in pediatric oncology
Marie Dutreix (Paris)
10.55
EXHIBITION & POSTERS
11.15
COFFEE BREAK
11.15
12.15
SELECTED ABSTRACTS
SESSION 1
Chairpersons: Sophie Pinel (Nancy) & Alexandre Detappe (Strasbourg)
11.15
Evaluating Tenascin C Effect on the Response of Breast Cancer Cell Lines,
Joyce Azzi, (Strasbourg)
11.30
Core-shell mesoporous nanocarriers for combined photothermia and drug delivery,
Damien Mertz, (Strasbourg)
11.45
Radiosensitization with gadolinium chelate-coated gold nanoparticles reduces glioblastoma invasiveness,
Sophie Pinel, (Nancy)
12.00
Photothermal efficiency of indocyanine green J-aggregates by nanoformulation with Calix[4]arene,
Marie Millard, (Nancy)
12.15
13.15
SATELLITE SYMPOSIUM 
GSK
Apport de la biologie moléculaire dans la prise en charge de cancers gynécologiques : focus cancers de l’ovaire et de l’endomètre
Pr Alexandre Harlé (ICL Nancy) et Dr Céline Gavoille (ICL Nancy)
13.15
EXHIBITION & POSTERS
14.00
LUNCH BREAK
14.00
OPENING ONCOTRANS
SESSION 2
“THERAPEUTIC & DIAGNOSTIC BIOMARKERS”
Chairpersons: Jean-Louis Merlin (Nancy), Christophe Borg (Besançon)
14.00
14.30
PLENARY 2.1
Clonal heterogeneity of solid tumors
Alexandre Harlé (Nancy)
14.35
15.05
PLENARY 2.2
Designing biomarker driven clinical trials : results from BioNIKK trial
Stéphane Oudard (Paris)
15.10
16.10
SELECTED ABSTRACTS
SESSION 2
Chairpersons: Aurélien Lambert (Nancy), Jérôme Devy (Reims)
15.10
Imaging of 3D Head and Neck Cancer Spheroids by Quantum Dots,
Luca Dirheimer, (Nancy)
15.25
PRMT2 is involved in acute myeloid leukemia through its role on inflammation,
Camille Sauter, (Dijon)
15.40
Therapeutic interest of an iron-based complex to improve treatments against pancreatic and triple negative breast cancer,
Camille Neybecker, (Nancy)
15.55
ITGB2 activates EGFR and mediates Erlotinib resistance in small cell lung cancer,
Guillermo Barreto, (Nancy)
16.10
EXHIBITION & POSTERS
16.40
COFFEE BREAK
16.45
17.45
Round table “Valorisation, Startups”
Chairpersons: Pierre Fumoleau (Strasbourg), Rachel Groubet (Strasbourg)
Incubateur Lorrain (Nancy), SATT Sayens (Dijon), Quest for Change (Strasbourg)
17.45
EXHIBITION & POSTERS
19.00
WELCOME COCKTAIL
Friday, November 4th
8.30
WELCOME
8.45
OPENING ONCOTRANS
SESSION 3
“IMMUNOLOGY, CELL THERAPY, CAR-T CELLS”
Chairpersons: Marie-Thérèse Rubio (Nancy), Céline Mascaux (Strasbourg)
9.00
9.30
PLENARY 3.1
Interest of immunomonitoring patients during CART cells therapy
Sophie Caillat-Zucman (Paris)
9.35
10.05
PLENARY 3.2
Beyond CTLA4 and PD1/PDL1 : new targets for antitumoral immunotherapy
Christophe Borg (Besançon)
10.10
EXHIBITION & POSTERS
10.40
COFFEE BREAK
10.40
11.40
SELECTED ABSTRACTS
SESSION 3
Chairpersons: Loïc Reppel (Nancy), C. Mascaux (Strasbourg)
10.40
In vitro model setup for tumor-associated neutrophils study in vitro: focus on osteosarcoma context,
Laura Vellutini, (Reims)
10.55
Improvement of the antitumor activity of Natural Killer cells without gene modification,
Mélanie Gauthier, (Nancy)
11.10
Radiotherapy Scheme Effect on PD-L1 Expression for Locally Advanced Rectal Cancer,
Jihane Boustani, (Besançon)
11.25
High-throughput preclinical screening of CD123 scFv to design 3rd generation of CAR T-cell,
Maxime Fredon, (Besançon)
11.45
12.45
SATELLITE SYMPOSIUM 
PIERRE FABRE ONCOLOGIE
Modérateur : Jean-Louis Merlin, (Nancy)
“BRAFV600 mutation from discovery to daily practice in melanoma and CRC”
Alexandre Harlé (Nancy) & Christophe Borg (Besançon)
12.45
EXHIBITION & POSTERS
13.30
LUNCH BREAK
13.00
WELCOME TO 4TH TUMOR LIQUID BIOPSY SYMPOSIUM
13.30
13.35
OPENING ONCOTRANS
SESSION 4 & 4TH TUMOR LIQUID BIOPSY SYMPOSIUM (TLBS)
PART 1 “LIQUID BIOPSIES IN THE CLINIC”
Chairpersons: Jean-Louis Merlin (Nancy), Florian Scherer (Freiburg), Alexandre Harlé (Nancy) & Justus Duyster (Freiburg)
13.35
14.35
KEYNOTE LECTURE 1
CTC and ctDNA : the long way from concept to clinical use
Klaus Pantel, (Hamburg) & Catherine Alix (Montpellier)
14.40
15.30
KEYNOTE LECTURE 2
Circulating tumor DNA for minimal residual disease detection : ready for prime time
Ash Alizadeh (Stanford CA)
15.30
EXHIBITION & POSTERS
16.00
COFFEE BREAK
16.00
16.30
PLENARY 4.1
Risk assessment and treatment stratification using ctDNA in GIST, Melanoma and Lung Cancer,
Nikolas Von Bubnoff (Lübeck)
16.30
18.00
SELECTED ABSTRACTS
ONCOTRANS / 4TH TLBS
Chairpersons: Alexandre Harlé (Nancy), Nikolas Von Bubnoff (Lübeck), Justus Duyster (Freiburg)
16.30
The role of circulating tumor DNA in patients with central nervous system lymphoma,
Florian Scherer, (Freiburg)
16.45
Genomic signatures in ctDNA from patient with advanced breast cancer treated with anti-aromatase,
Margaux Betz, (Nancy)
17.00
Blood and urine based liquid profiling of telomerase reverse transcriptase (TERT) C228T and C250T,
Matthias Mack, (Munich)
17.15
Profiling of circulating tumor DNA for comprehensive tumor genotyping,
Lavanya Ranganathan, (Freiburg)
17.30
Determination of Homologous Recombination Deficiency using liquid biopsy in patients with ovarian cancer,
Alexandre Harlé, (Nancy)
17.45
Therapeutic drug monitoring and circulating tumor DNA in patients with BRAF-mutated metastatic cutaneous melanoma,
Albane L’Huillier, (Nancy)
18.00
EXHIBITION & POSTERS
19.30
AWARDS ONCOTRANS
Saturday, November 5th
8.15
WELCOME
8.30
OPENING DAY 2 – 4TH TLBS
Jean-Louis Merlin (Nancy), Florian Scherer (Freiburg)
8.45
9.00
4TH TLBS PART 2 “INNOVATIVE TECHNIQUES AND APPLICATIONS IN LIQUID BIOPSY”
Chairpersons: Alexandre Harle (Nancy), Nikolas von Bubnoff (Lübeck)
9.00
9.30
PLENARY 4TH TLBS 1
Genomic and epigenomic analysis of cell-free DNA in Cancer
Holger Sültmann (Heidelberg)
9.35
10.05
PLENARY 4TH TLBS 2
Mining cell-free DNA biology to boost liquid biopsy
Florent Moulière (Amsterdam)
10.05
EXHIBITION & POSTERS
10.35
COFFEE BREAK
10.35
11.40
SELECTED ABSTRACTS 4th TLBS
Chairpersons: Romain Boidot (Dijon), Florian Scherer (Freiburg)
10.35
Ultra-sensitive monitoring of leukemia patients using superRCA mutation detection assays,
Tomas Edgren, Rarity Bioscience (Uppsala)
10.50
Epitranscriptomics”: a promising source of circulating biomarkers for personalized medicine,
Amandine Amalric, (Montpellier)
11.05
BrightSens Diagnostics: new technology for RNA detection in liquid biopsies,
John Volke, Brightsens diagnostics (Strasbourg)
11.20
Epigenetic biomarkers of melanoma: bioinformatics analysis of public data and proof of concept,
Anes Hadjadj-Aoul, (Besançon)
11.35
Clinical interest of exosomes: biomarker and therapeutic target in oncology,
Jessica Gobbo, (Dijon)
12.00
12.15
4TH TLBS AWARDS & CLOSING REMARKS
Florian Scherer (Freiburg), Florence Schaffner (Strasbourg), Jean-Louis Merlin (Nancy)
12.30
End
